@ARTICLE{muehlbacher06b,
  author = {F. M{\"u}hlbacher and H. Schiessel and C. Holm},
  title = {Tail-induced attraction between nucleosome core particles},
  journal = {Phys. Rev. E},
  year = {2006},
  volume = {74},
  pages = {031919},
  abstract = {We study a possible electrostatic mechanism underlying the compaction
	of DNA inside the nuclei of eu- caryotes: the tail-bridging effect
	between nucleosomes, the fundamental DNA packaging units of the chromatin
	complex. As a simple model of the nucleosome we introduce the eight-tail
	colloid, a charged sphere with eight oppositely charged, flexible,
	grafted chains that represent the terminal histone tails. We show
	that our com- plexes attract each other via the formation of chain
	bridges and contrast this to the effect of attraction via charge
	patches. We demonstrate that the attraction between eight-tail colloids
	can be tuned by changing the fraction of charged monomers on the
	tails. This suggests a physical mechanism of chromatin compaction
	where the degree of DNA condensation is controlled via biochemical
	means, namely the acetylation and deacetylation of lysines in the
	histone tails.},
  file = {muehlbacher06b.pdf:muehlbacher06b.pdf:PDF},
  owner = {holm},
  timestamp = {2006.10.03}
}